A road less traveled by: Exploring a decade of Ellman chemistry

The Road Less Traveled

As I look down the hill through the editorial office’s window, I notice a sprout developing on a pine tree blooming nearby. I then pat myself on the back thinking of the last 3 months I have gone through. It was snowing when I first began the managing editorship for Osong Public Health and Research Perspectives. The first issue has already been published, with its glossy cover now reflecting in...

The road less traveled.

The road less traveled

Phagosomes containing the bacterial pathogen Legionella pneumophila are transported to the ER after macrophage internalization. To modulate phagosome transport, Legionella use a specialized secretion system that injects bacterial proteins into eukaryotic cells. This review will focus on recent studies that have identified bacterial proteins and host processes that play a concerted role in trans...

The road less traveled

Traditional approaches for salvaging peri-odontally involved teeth have faced the test of whether or not the treatment modalities can guarantee tooth survival for more than a couple of decades. This challenge stems from the most recent encouraging reports of a success rate of over 15 years of implant therapy to treat partial edentulism. The main criticism of traditional periodontal therapy targ...

A road less traveled paved by IDO silencing

Orchestrating a cytotoxic polymorphonuclear neutrophil (PMN) response strictly focused within the tumor tissue remains a formidable challenge for the successful therapeutic use of these cells. A Salmonella vector carrying an shRNA against indoleamine 2,3-dioxygenase has been shown to recruit PMNs and enhance their activation specifically in the tumor bed, resulting in significant anticancer eff...